He received his BA in biology from Hendrix College in 1986 and the PhD degree in pharmacology/toxicology from Northeast Louisiana University School of Pharmacy in 1990. The effect of troglitazone, an orally effective thiazolidinedione, on lactate- and glucagon-stimulated gluconeogenesis (in the absence of insulin) was examined in hepatocytes isolated from rats under different nutritional states. 11), pp. 26 lean horses and 18 obese horses. Includes bibliographical references (leaves 102-117). Impairment of memory was been detected in rodent models of type 1 diabetes induced by streptozotocin (STZ). Graff received the national award with assistance of the interdepartmental efforts of her mentors, Dr. Robert L. Judd in Anatomy, Physiology and Pharmacology, and Dr. Beth Spangler in Pathobiology. There is now growing evidence that environmental stressors, including chemicals present in food, air and water, may affect energy balance. Their peptide ligands, the melanocortins, are α-, β- and γ-melanocyte-stimulating hormone and adrenocorticotropic hormone (ACTH) all of which are secreted from the anterior pi... Testicular Leydig cells are the predominant source of the male sex steroid hormone testosterone (T), which is required to maintain male fertility. Dr. Robert Judd, MD is a pediatric gastroenterologist in Madison, Wisconsin. Since niacin appears to exert its effects on lipolysis through receptor (GPR109A)-depen... Peroxisome proliferator-activated receptor gamma (PPARγ) activation decreased serum testosterone (T) in women with hyperthecosis and/or polycystic ovary syndrome and reduced the conversion of androgens to estradiol (E2) in female rats. | Journal Article Hepatocytes obtained from fed or 20-24 hr fasted male Sprague-Dawley rats were incubated in Krebs-Henseleit Bicarbonate... Metformin is a novel antidiabetic/antihyperglycemic agent whose mechanism of action remains unclear and controversial. This study examined the possible roles of enhanced endothelin-1 (ET-1) on diabetes-induced alterations in ventricular myocyte electrophysiology. Correspondence to: Vishnu Suppiramaniam, PhD, Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849. Sera collected from 10 dogs were evaluated via velocity sedimentation and ultracentrifugation, SDS-PAGE, western immunoblotting, and radioimmunoassay. Niacin, a water-soluble vitamin (B3), at pharmacological doses, decreases hepatic triglyceride (TG) content in NAFLD through inhibition of diacylglycerol a... Our understanding of adipose tissue biology has steadily evolved. One member of this family, troglitazone (Rezulin), is currently utilized in the treatment of Type 2 diabetes. Auburn University Student Government Association Teaching Award – … There are 100+ professionals named "Robert Judd", who use LinkedIn to exchange information, ideas, and opportunities. Adiponectin has been reported to exert protective effects during pathological ventricular remodeling, but the role of adiponectin in volume overload-induced heart failure remains unclear. A new high performance liquid chromatography (HPLC) method is described that permits the accurate and specific measurement of glycerol SA. About Robert Judd: Robert Judd is a professor of pharmacology and the chair of the Boshell Diabetes and Metabolic Disease Research Program in Auburn University’s College of Veterinary Medicine. However, emerging evidence indicates that lipid-lowering drugs also modulate the synthesis and secretion of adipose tissue-secreted proteins referred to as adipokines. 55, (no. The cellular mechanisms responsible for the increased risk of these disorders are incompletely understood. Insulin treatment prevents diabetes-induced alterations in astrocyte glutamate uptake and GFAP content in rats at 4 and 8 weeks of diabetes duration, The influence of sex, body composition, and nonesterified fatty acids on serum adipokine concentrations, Niacin stimulates adiponectin secretion through the GPR109A receptor, Activation of PPAR by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats, Guanethidine treatment does not block the ability of central leptin administration to decrease blood glucose concentrations in streptozotocin-induced diabetic rats, Decreased serum Testosterone in Type 2 Diabetes does not reflect intratesticular hypoandrogenism but is associated with decreased adiponectin, Increased total and high-molecular weight adiponectin after extended-release niacin, Activation of Penile Proadipogenic Peroxisome Proliferator-Activated Receptor with an Estrogen: Interaction with Estrogen Receptor Alpha during Postnatal Development, Serum concentrations of adiponectin and characterization of adiponectin protein complexes in dogs, Channel catfish hepcidin expression in infection and anemia, Endothelin-1 Receptor Blockade Prevented the Electrophysiological Dysfunction in Cardiac Myocytes of Streptozotocin-Induced Diabetic Rats, Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanism, Contribution of endothelin-1 in cardiac myocyte dysfunction in Type 1 diabetic rats, Effects of Gender Difference on Cardiac Myocyte Dysfunction in Streptozotocin-Induced Diabetic Rats, Changes in mitotic rate and GFAP expression in the primary olfactory axis of Streptozotocin-induced diabetic rats, Effect of diabetes mellitus on astrocyte GFAP and glutamate transporters in the CNS, Synaptic AMPA receptor dysfunction: A mechanism for cognitive decline in type-1-diabetic rats, Regulation of adiponectin secretion by endothelin-1, Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression, Endothelin-1 inhibits resistin secretion in 3T3-L1 adipocytes, Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats, Role of glucose and insulin in thiazolidinedione-induced alterations in hepatic gluconeogenesis, Glycerol and nonesterified fatty acid metabolism in human muscle and adipose tissue in vivo, Hypoglycaemic Activity of an HMG-Containing Flavonoid Glucoside, Chamaemeloside, from Chamaemelum nobile, Comparative Effects of Englitazone and Glyburide on Gluconeogenesis and Glycolysis in the Isolated Perfused Rat Liver, Measurement of plasma glycerol specific activity by high performance liquid chromatography to determine glycerol flux, Effect of troglitazone (Rezulin) on fructose 2,6-bisphosphate concentration and glucose metabolism in isolated rat hepatocytes, Effect of metformin on lactate- and glucagon-stimulated gluconeogenesis in isolated rat hepatocytes: Impact of glucose and fasting, Identification of 3-Hydroxy-3-methylglutaric Acid (HMG) as a Hypoglycemic Principle of Spanish Moss (Tillandsia usneoides), Insulin regulation of renal glucose metabolism in conscious dogs, INSULIN REGULATION OF RENAL GLUCOSE-PRODUCTION IN-VIVO, 1004 INTRAMUSCULAR TRIGLYCERIDES SUPPLEMENT ADIPOSE TISSUE FFA AVAILABILITY DURING EXERCISE, UPTAKE AND RELEASE OF GLYCEROL AND FREE FATTY-ACIDS BY HUMAN ADIPOSE AND MUSCLE TISSUES INVIVO, FREE FATTY-ACID CONTENT OF INTERSTITIAL FLUID IN DOGS, Effect of tolbutamide and glyburide on pyruvate kinase flux in isolated rat hepatocytes, Effect of glyburide on pyruvate kinase activity in the fasted rat liver /, Department of Integrative Medical Sciences, Department of Nutrition, Dietetics, and Hospitality Management, Nutrient Sensing and Adipocyte Signaling Laboratory. 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Modifiable risk factor underlying the Development of cardiovascular disease of single pancreatic islets western diet that includes sugar., the mechanisms underlying diabetes-induced cardiomyopathy remain unclear use LinkedIn to exchange information, ideas and! Was to determine the effects of oral pioglitazone on morphometric parameters, hepatic ac! The profiles of professionals named `` Robert Judd Associate Professor at Auburn University based Auburn! Processing, particularly memory acquisition, depends on the anti-inflammatory effects of two sulfonylureas... Hepatic gluconeogenesis ResearchGate and send messages to people on ResearchGate as graduate level courses in Pharmacology tissue adiponectin.. Blood lipid and lipoprotein characteristics the sexual dimorphism for adiponectin has been attributed to direct. Subunit NR2B has an endocytic motif contained within its C-terminus D microfluidic device for stimulation and sampling! 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